In large scale clinical trials funded by the National Eye Institute, the AREDS2 formula benefited people with intermediate or late age-related macular degeneration (AMD). There was no tangible benefit for people with early AMD or for people who do not have AMD. Keep in mind though that nutritional supplements cannot prevent AMD. However, the AREDS2 supplements may delay the progression of intermediate to advanced AMD and may help you keep your central vision longer.
The high levels of vitamins and minerals found in these supplements are difficult to achieve from diet alone. However, previous studies have suggested that people who have diets rich in green, leafy vegetables—a good source of lutein and zeaxanthin—have a lower risk of developing AMD. In the AREDS2 trial, the participants who benefited most from taking lutein + zeaxanthin were those who did not get much of these nutrients in their diet. Within this group, those who received lutein/zeaxanthin supplements had a 26% reduced risk of developing advanced AMD compared with those who did not receive the supplements.
Bausch & Lomb produced the formulations for the clinical trials and their Preservision AREDS2 products are the supplements we recommend. They are available without a prescription online and at the major pharmacies and grocery stores.